How Johnson & Johnson’s Vaccine Differs From Pfizer and Moderna’s

A 3rd efficient weapon was added to America’s arsenal towards the coronavirus on Saturday when the Meals and Drug Administration granted emergency use authorization for a vaccine developed by Johnson & Johnson.

The corporate mentioned it will begin delivery hundreds of thousands of doses early this week, and would offer the USA with 100 million doses by the tip of June. Along with 600 million doses of the nation’s first two approved vaccines, made by Pfizer-BioNTech and Moderna, which might be on account of be delivered over the following 4 months, that must be sufficient to cowl each American grownup who desires to be vaccinated.

The brand new vaccine differs markedly from the 2 already in use in the USA. Right here is how they examine.

The Johnson & Johnson vaccine is run in a single shot, whereas the Pfizer-BioNTech and Moderna vaccines are given in two photographs a number of weeks aside.

The Johnson & Johnson vaccine makes use of a distinct methodology to prime the physique to struggle off Covid-19: a viral vector called Ad26. Viral vectors are common viruses that have been genetically altered so that they do not cause illness but can still cause the immune system to build up its defenses. The Pfizer-BioNTech and Moderna vaccines use messenger RNA to do that.

The Johnson & Johnson vaccine is rated as highly effective at preventing serious illness and death, as the Pfizer-BioNTech and Moderna vaccines are. It is also very effective at preventing milder illness, though a bit less so than those two. It appears to do well against the highly contagious B.1.351 variant, first identified in South Africa, that has given at least one other vaccine candidate trouble.

The Johnson & Johnson vaccine does not have to be stored at extremely low temperatures like the Pfizer-BioNTech vaccine. It can safely be kept in an ordinary refrigerator for three months, much longer than the Moderna vaccine, which spoils after a month if not kept frozen.

The Johnson & Johnson vaccine appears to be less prone than the Pfizer-BioNTech and Moderna vaccines to trigger the kinds of side effects that require monitoring after the injection, which may make it more suitable for use at drive-through vaccination sites. There have been reports that side effects tend to be felt more strongly after second doses, which the Johnson & Johnson vaccine does not require.

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